Details of the Target

General Information of Target

Target ID LDTP15848
Target Name Spindlin-2A (SPIN2A)
Gene Name SPIN2A
Gene ID 54466
Synonyms
DXF34; SPIN2; Spindlin-2A; Protein DXF34; Spindlin-like protein 2A; SPIN-2; SPIN-2A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGLDACELGAQLLELLRLALCARVLLADKEGGPPAVDEVLDEAVPEYRAPGRKSLLEIR
QLDPDDRSLAKYKRVLLGPLPPAVDPSLPNVQVTRLTLLSEQAPGPVVMDLTGDLAVLKD
QVFVLKEGVDYRVKISFKVHREIVSGLKCLHHTYRRGLRVDKTVYMVGSYGPSAQEYEFV
TPVEEAPRGALVRGPYLVVSLFTDDDRTHHLSWEWGLCICQDWKD
Target Bioclass
Other
Family
SPIN/STSY family
Subcellular location
Nucleus
Function May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity.
Uniprot ID
Q99865
Ensemble ID
ENST00000374906.4
HGNC ID
HGNC:20694

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C56(1.16)  LDD3395  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C56(1.19)  LDD2254  [1]
 LDCM0023  KB03 ABC-1 C56(0.99)  LDD2679  [1]
 LDCM0024  KB05 PC-3 C56(1.16)  LDD3395  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840