General Information of Target

Target ID LDTP15826
Target Name Phosphatidylethanolamine-binding protein 4 (PEBP4)
Gene Name PEBP4
Gene ID 157310
Synonyms
CORK1; Phosphatidylethanolamine-binding protein 4; PEBP-4; hPEBP4; Protein cousin-of-RKIP 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPSRQPPPGGSGLLQGSRARSYGSLVQSACSPVRERRLEHQLEPGDTLAGLALKYGVT
MEQIKRANRLYTNDSIFLKKTLYIPILTEPRDLFNGLDSEEEKDGEEKVHPSNSEVWPHS
TERKKQETGAGRANGEVLPTPGQETPTPIHDLSASDFLKKLDSQISLSKKAAAQKLKKGE
NGVPGEDAGLHLSSPWMQQRAVLGPVPLTRTSRTRTLRDQEDEIFKL
Target Bioclass
Other
Family
Phosphatidylethanolamine-binding protein family
Subcellular location
Secreted
Function Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
Uniprot ID
Q96S96
Ensemble ID
ENST00000256404.8
HGNC ID
HGNC:28319

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info 
N.A.  LDD0447  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.