Details of the Target

General Information of Target

Target ID LDTP15812
Target Name Pleckstrin homology domain-containing family G member 4B (PLEKHG4B)
Gene Name PLEKHG4B
Gene ID 153478
Synonyms
KIAA1909; Pleckstrin homology domain-containing family G member 4B; PH domain-containing family G member 4B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEEVWMGTWRPHRPRGPIMALYSSPGPKYLIPPTTGFMKHTPTKLRAPAYSFRGAPMLL
AENCSPGPRYNVNPKILRTGKDLGPAYSILGRYQTKTMLTPGPGDYFPEKSTKYVFDSAP
SHSISARTKAFRVDSTPGPAAYMLPMVMGPNTVGKASQPSFSIKGRSKLGGFSDDLHKTP
GPAAYRQTDVRVTKFKAPQYTMAARVEPPGDKTLKPGPGAHSPEKVTLTKPCAPVVTFGI
KHSDYMTPLLVDVE
Target Bioclass
Other
Uniprot ID
Q96PX9
Ensemble ID
ENST00000283426.11
HGNC ID
HGNC:29399

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C956(1.53)  LDD2260  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A-549 C956(1.53)  LDD2260  [1]
 LDCM0023  KB03 ABC-1 C956(8.39); C233(4.08)  LDD2679  [1]
 LDCM0024  KB05 A-549 C956(1.05)  LDD3094  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Four and a half LIM domains protein 3 (FHL3) . Q13643

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840