Details of the Target

General Information of Target

Target ID LDTP15797
Target Name Zinc finger protein 599 (ZNF599)
Gene Name ZNF599
Gene ID 148103
Synonyms
Zinc finger protein 599
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELHYLAKKSNQADLCDARDWSSRGLPGDQADTAATRAALCCQKQCASTPRATEMEGSKL
SSSPASPSSSLQNSTLQPDAFPPGLLHSGNNQITAERKVCNCCSQELETSFTYVDKNINL
EQRNRSSPSAKGHNHPGELGWENPNEWSQEAAISLISEEEDDTSSEATSSGKSIDYGFIS
AILFLVTGILLVIISYIVPREVTVDPNTVAAREMERLEKESARLGAHLDRCVIAGLCLLT
LGGVILSCLLMMSMWKGELYRRNRFASSKESAKLYGSFNFRMKTSTNENTLELSLVEEDA
LAVQS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q96NL3
Ensemble ID
ENST00000329285.13
HGNC ID
HGNC:26408

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.S112Y .
CAL27 SNV: p.A235S .
COLO792 SNV: p.H249Y .
DEL SNV: p.P137T .
K562 SNV: p.E392K .
LNCaP clone FGC SNV: p.D182G .
RH41 SNV: p.F572V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		S94(0.00); S99(0.00); S102(0.00)  LDD0245  [1]
HHS-465
 Probe Info  		K253(0.00); K256(0.00); Y255(0.00)  LDD2240  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010