Details of the Target

General Information of Target

Target ID LDTP15790
Target Name Cilia- and flagella-associated protein 54 (CFAP54)
Gene Name CFAP54
Gene ID 144535
Synonyms
C12orf55; C12orf63; Cilia- and flagella-associated protein 54
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVTHAAGARTFCEEQKKGSTYSVPKSKEKLMEKHSQEARQADRESEKPVDSLHPGAGTAK
HPPPAASLEEKPDVKQKSSRKKVVVPQIIITRASNETLVSCSSSGSDQQRTIREPEDWGP
YRRHRNPSTADAYNSHLKE
Target Bioclass
Other
Family
CFAP54 family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function Required for assembly and function of cilia and flagella.
Uniprot ID
Q96N23
Ensemble ID
ENST00000524981.9
HGNC ID
HGNC:26456

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.V2987D .
A431 SNV: p.D2589H .
AGS SNV: p.A1859S .
AN3CA Deletion: p.M1234CfsTer31 .
CAL148 SNV: p.S2500C .
CAL51 SNV: p.A446T .
COLO678 SNV: p.L1690S .
COLO679 SNV: p.E1579K .
DU145 SNV: p.A2492S .
GB1 SNV: p.T2356A .
HCT116 SNV: p.Y151H; p.L562Ter .
HCT15 SNV: p.F1470S; p.L2169R .
HEC1 SNV: p.D2488N .
HEP3B217 SNV: p.V2551I .
HEPG2 SNV: p.D1364E .
HT115 SNV: p.A848S; p.D2653N .
IGROV1 SNV: p.L284F; p.P1562T .
IM95 SNV: p.D2831G .
JURKAT SNV: p.A2188T .
KASUMI1 SNV: p.P1731T .
KMCH1 SNV: p.T809N .
KMRC1 SNV: p.T2411S .
KPL1 SNV: p.L1087P .
LN18 SNV: p.F488C .
MCC13 SNV: p.P1963L; p.R2530C .
MFE296 SNV: p.V606F .
MOLT4 Deletion: p.S2426AfsTer12 .
MSTO211H SNV: p.P965L .
NCIH1299 SNV: p.N538S; p.A848E .
NCIH146 SNV: p.N1440K .
NCIH1793 SNV: p.M2410I .
NCIH2286 SNV: p.A963T; p.G2674Ter .
NCIH358 SNV: p.A2607P .
NCIH661 SNV: p.F1728I .
NOMO1 SNV: p.S2837Y .
OVCAR8 SNV: p.L2087P .
SKMEL2 SNV: p.L1650P .
SKMEL30 SNV: p.E1350K .
SKMEL5 SNV: p.D2346N .
SNU1 Deletion: p.R1557EfsTer19 .
SNU245 SNV: p.L2030F .
TE4 SNV: p.S2500C .
UACC62 SNV: p.S2022F .
UMUC3 SNV: p.P283L .
VCAP SNV: p.V933G .
WM793 SNV: p.Q1637Ter .
YSCCC SNV: p.D1661H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0217  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0107  IAA HeLa N.A.  LDD0221  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.