Details of the Target
General Information of Target
| Target ID | LDTP15789 | |||||
|---|---|---|---|---|---|---|
| Target Name | Spermatogenesis-associated protein 33 (SPATA33) | |||||
| Gene Name | SPATA33 | |||||
| Gene ID | 124045 | |||||
| Synonyms |
C16orf55; Spermatogenesis-associated protein 33 |
|||||
| 3D Structure | ||||||
| Sequence |
MSAFEKPQIIAHIQKGFNYTVFDCKWVPCSAKFVTMGNFARGTGVIQLYEIQHGDLKLLR
EIEKAKPIKCGTFGATSLQQRYLATGDFGGNLHIWNLEAPEMPVYSVKGHKEIINAIDGI GGLGIGEGAPEIVTGSRDGTVKVWDPRQKDDPVANMEPVQGENKRDCWTVAFGNAYNQEE RVVCAGYDNGDIKLFDLRNMALRWETNIKNGVCSLEFDRKDISMNKLVATSLEGKFHVFD MRTQHPTKGFASVSEKAHKSTVWQVRHLPQNRELFLTAGGAGGLHLWKYEYPIQRSKKDS EGIEMGVAGSVSLLQNVTLSTQPISSLDWSPDKRGLCVCSSFDQTVRVLIVTKLNKI |
|||||
| Target Bioclass |
Other
|
|||||
| Subcellular location |
Cytoplasm, cytosol
|
|||||
| Function |
Plays an important role in sperm motility and male fertility. Required for sperm midpiece flexibility and for the localization of sperm calcineurin to the mitochondria. Promotes mitophagy as well as acts as an autophagy mediator in male germline cells. Links damaged mitochondria to autophagosomes via its binding to the outer mitochondrial membrane protein VDAC2, as well as to key autophagy machinery component ATG16L1.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C102(2.09) | LDD3373 | [1] | |
|
IPM Probe Info |
 |
N.A. | LDD0025 | [2] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2224 | [3] | |
|
TFBX Probe Info |
 |
N.A. | LDD0027 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References