Details of the Target

General Information of Target

Target ID	LDTP15780
Target Name	Coiled-coil domain-containing protein 7 (CCDC7)
Gene Name	CCDC7
Gene ID	79741
Synonyms	BIOT2; C10orf68; Coiled-coil domain-containing protein 7; Protein BIOT2
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MATSERALLRTRAASLLRGLGRSRTGARSLQFRAEKERQPCWSFPMGQKTKGSSNIASSY LLQQLMHRYQELDSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGR SGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQ NNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLI HLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLEN HDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD QKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQPQRIFDSTLPSLDAPYPMLILA GPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKF ILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKY EGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYL GLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGDFLHSTDRNYLIKFWAKLSAKKTP AERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCED YFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEET RKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPIPQGRR
Target Bioclass	Other
Function	May play a role in tumorigenesis.
Uniprot ID	Q96M83
Ensemble ID	ENST00000277657.12
HGNC ID	HGNC:26533

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
CCK81	SNV: p.K970N	.
FADU	SNV: p.R490P	.
HCC1395	SNV: p.S454L	.
HKGZCC	SNV: p.I996F	.
J82	SNV: p.H709R	.
MCC13	SNV: p.I996T	.
MFE319	SNV: p.V344M	.
NCIH146	SNV: p.L154W	.
OVCAR8	SNV: p.L383P	.
RKO	Deletion: p.N558TfsTer4	.
SW480	SNV: p.T1245P	.
SW948	SNV: p.L394W	.
TKKK	SNV: p.Q834H	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
1d-yne Probe Info			N.A.	LDD0356	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Huntingtin (HTT)				Huntingtin family	P42858
Nuclear RNA export factor 1 (NXF1)				NXF family	Q9UBU9

References

1	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.