Details of the Target

General Information of Target

Target ID LDTP15736
Target Name SH3 domain-containing YSC84-like protein 1 (SH3YL1)
Gene Name SH3YL1
Gene ID 26751
Synonyms
SH3 domain-containing YSC84-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALGSPSHTFRGLLRELRYLSAATGRPYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELH
FQAATYLCLLRSIRKHVALHQEFHGKGERSVEESAGLVGLKLPHQPGGKGWEP
Target Bioclass
Other
Family
SH3YL1 family
Uniprot ID
Q96HL8
Ensemble ID
ENST00000356150.10
HGNC ID
HGNC:29546

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.P32S .
HCT15 SNV: p.V68A .
MEWO SNV: p.L207F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C57(2.27)  LDD2268  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C57(2.27)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C57(5.51)  LDD2685  [1]
 LDCM0024  KB05 BRX211 C57(2.48)  LDD3102  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 7B (ZBTB7B) . O15156
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
SH3 domain-containing protein 19 (SH3D19) . Q5HYK7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060