Details of the Target

General Information of Target

Target ID LDTP15729
Target Name Distal membrane-arm assembly complex protein 1 (DMAC1)
Gene Name DMAC1
Gene ID 90871
Synonyms
C9orf123; TMEM261; Distal membrane-arm assembly complex protein 1; Transmembrane protein 261
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGTLEKVLCLRNNTIFKQAFSLLRFRTSGEKPIYSVGGILLSISRPYKTKPTHGIGKYK
HLIKAEEPKKKKGKVEVRAINLGTDYEYGVLNIHLTAYDMTLAESYAQYVHNLCNSLSIK
VEESYAMPTKTIEVLQLQDQGSKMLLDSVLTTHERVVQISGLSATFAEIFLEIIQSSLPE
GVRLSVKEHTEEDFKGRFKARPELEELLAKLK
Target Bioclass
Other
Subcellular location
Mitochondrion inner membrane
Function Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.
Uniprot ID
Q96GE9
Ensemble ID
ENST00000358227.5
HGNC ID
HGNC:30536

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C50(1.14)  LDD1701  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0023  KB03 MDA-MB-231 C50(1.14)  LDD1701  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.