Details of the Target

General Information of Target

Target ID LDTP15723
Target Name Kinesin-like protein KIF12 (KIF12)
Gene Name KIF12
Gene ID 113220
Synonyms
Kinesin-like protein KIF12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEPEMQLKGKKVTDKFTESVYVLANEPSVALYRLQEHVRRSLPELAQHKADMQRWEEQS
QGAIYTVEYACSAVKNLVDSSVYFRSVEGLLKQAISIRDHMNASAQGHSPEEPPPPSSA
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Subcellular location
Cytoplasm, cytoskeleton
Uniprot ID
Q96FN5
HGNC ID
HGNC:21495

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C632(3.13)  LDD3389  [1]
N1
 Probe Info  		S171(0.00); S174(0.00)  LDD0245  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC4 C632(1.62)  LDD2392  [1]
 LDCM0023  KB03 ICC19 C632(1.67)  LDD2803  [1]
 LDCM0024  KB05 OZ C632(3.13)  LDD3389  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.