Details of the Target

General Information of Target

Target ID LDTP15722
Target Name BLOC-1-related complex subunit 8 (BORCS8)
Gene Name BORCS8
Gene ID 729991
Synonyms
MEF2BNB; BLOC-1-related complex subunit 8; MEF2B neighbor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVPRLDHALNSPTSPCEEVIKNLSLEAIQLCDRDGNKSQDSGIAEMEELPVPHNIKISN
ITCDSFKISWEMDSKSKDRITHYFIDLNKKENKNSNKFKHKDVPTKLVAKAVPLPMTVRG
HWFLSPRTEYTVAVQTASKQVDGDYVVSEWSEIIEFCTADYSKVHLTQLLEKAEVIAGRM
LKFSVFYRNQHKEYFDYVREHHGNAMQPSVKDNSGSHGSPISGKLEGIFFSCSTEFNTGK
PPQDSPYGRYRFEIAAEKLFNPNTNLYFGDFYCMYTAYHYVILVIAPVGSPGDEFCKQRL
PQLNSKDNKFLTCTEEDGVLVYHHAQDVILEVIYTDPVDLSVGTVAEITGHQLMSLSTAN
AKKDPSCKTCNISVGR
Target Bioclass
Other
Family
BORCS8 family
Subcellular location
Lysosome membrane
Function
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
Uniprot ID
Q96FH0
Ensemble ID
ENST00000462790.8
HGNC ID
HGNC:37247

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.V30M .
NCIH1993 SNV: p.D99E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C71(1.22)  LDD1508  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C71(1.22)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C71(1.16)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C71(1.15)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C71(1.28)  LDD1525  [1]
 LDCM0295  AC34 HEK-293T C71(1.16)  LDD1534  [1]
 LDCM0304  AC42 HEK-293T C71(1.12)  LDD1543  [1]
 LDCM0313  AC50 HEK-293T C71(1.37)  LDD1552  [1]
 LDCM0321  AC58 HEK-293T C71(1.34)  LDD1560  [1]
 LDCM0367  CL1 HEK-293T C71(1.17)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C71(1.26)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C71(1.46)  LDD1575  [1]
 LDCM0374  CL105 HEK-293T C71(1.09)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C71(1.22)  LDD1579  [1]
 LDCM0378  CL109 HEK-293T C71(1.20)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C71(1.48)  LDD1584  [1]
 LDCM0383  CL113 HEK-293T C71(1.49)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C71(1.41)  LDD1588  [1]
 LDCM0387  CL117 HEK-293T C71(1.34)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C71(1.27)  LDD1592  [1]
 LDCM0392  CL121 HEK-293T C71(1.25)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C71(1.41)  LDD1597  [1]
 LDCM0396  CL125 HEK-293T C71(1.39)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C71(1.53)  LDD1601  [1]
 LDCM0400  CL13 HEK-293T C71(1.23)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C71(1.51)  LDD1605  [1]
 LDCM0405  CL18 HEK-293T C71(1.59)  LDD1609  [1]
 LDCM0407  CL2 HEK-293T C71(1.30)  LDD1611  [1]
 LDCM0413  CL25 HEK-293T C71(1.08)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C71(1.29)  LDD1618  [1]
 LDCM0419  CL30 HEK-293T C71(1.23)  LDD1623  [1]
 LDCM0426  CL37 HEK-293T C71(1.29)  LDD1630  [1]
 LDCM0432  CL42 HEK-293T C71(1.05)  LDD1636  [1]
 LDCM0439  CL49 HEK-293T C71(1.31)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C71(1.16)  LDD1645  [1]
 LDCM0445  CL54 HEK-293T C71(1.30)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C71(1.23)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C71(1.20)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C71(1.27)  LDD1657  [1]
 LDCM0458  CL66 HEK-293T C71(1.15)  LDD1661  [1]
 LDCM0466  CL73 HEK-293T C71(1.50)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C71(1.23)  LDD1670  [1]
 LDCM0471  CL78 HEK-293T C71(1.16)  LDD1674  [1]
 LDCM0479  CL85 HEK-293T C71(1.21)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C71(1.68)  LDD1683  [1]
 LDCM0485  CL90 HEK-293T C71(1.58)  LDD1688  [1]
 LDCM0492  CL97 HEK-293T C71(1.23)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C71(1.35)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C71(1.31)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377