General Information of Target

Target ID LDTP15710
Target Name Methyl-CpG-binding domain protein 6 (MBD6)
Gene Name MBD6
Gene ID 114785
Synonyms
KIAA1887; Methyl-CpG-binding domain protein 6; Methyl-CpG-binding protein MBD6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPPAGLRRAAPLTAIALLVLGAPLVLAGEDCLWYLDRNGSWHPGFNCEFFTFCCGTCYHR
YCCRDLTLLITERQQKHCLAFSPKTIAGIASAVILFVAVVATTICCFLCSCCYLYRRRQQ
LQSPFEGQEIPMTGIPVQPVYPYPQDPKAGPAPPQPGFIYPPSGPAPQYPLYPAGPPVYN
PAAPPPYMPPQPSYPGA
Target Bioclass
Other
Subcellular location
Nucleus
Function Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
Uniprot ID
Q96DN6
Ensemble ID
ENST00000355673.8
HGNC ID
HGNC:20445

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C60(1.67)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCT 116 C60(1.67)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C60(1.39)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C60(1.53)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.