General Information of Target

Target ID LDTP15708
Target Name Enoyl-CoA hydratase domain-containing protein 3, mitochondrial (ECHDC3)
Gene Name ECHDC3
Gene ID 79746
Synonyms
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSVQVKLGDS
WDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMYTSKDRYFYFGKLDGQISSAY
PSQEGQVLVGIYGQYQLLGIKSIGFEWNYPLEEPTTEPPVNLTYSANSPVGR
Target Bioclass
Enzyme
Family
Enoyl-CoA hydratase/isomerase family
Subcellular location
Mitochondrion
Function May play a role in fatty acid biosynthesis and insulin sensitivity.
Uniprot ID
Q96DC8
Ensemble ID
ENST00000379215.9
HGNC ID
HGNC:23489

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info 
K293(2.94)  LDD0277  [1]
DBIA
 Probe Info 
C52(1.03)  LDD3350  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 8305C C52(1.35)  LDD2248  [2]
 LDCM0023  KB03 8305C C52(1.55)  LDD2665  [2]
 LDCM0024  KB05 NCl-H1944 C52(1.03)  LDD3350  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840