Details of the Target

General Information of Target

Target ID LDTP15703
Target Name Nucleoredoxin-like protein 1 (NXNL1)
Gene Name NXNL1
Gene ID 115861
Synonyms
TXNL6; Nucleoredoxin-like protein 1; Thioredoxin-like protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDMAQEPVTFRDVAIYFSREEWACLEPSQRALYRDVMLDNFSSVAALGFCSPRPDLVSRL
EQWEEPWVEDRERPEFQAVQRGPRPGARKSADPKRPCDHPAWAHKKTHVRRERAREGSSF
RKGFRLDTDDGQLPRAAPERTDAKPTAFPCQVLTQRCGRRPGRRERRKQRAVELSFICGT
CGKALSCHSRLLAHQTVHTGTKAFECPECGQTFRWASNLQRHQKNHTREKPFCCEACGQA
FSLKDRLAQHRKVHTEHRPYSCGDCGKAFKQKSNLLRHQLVHTGERPFYCADCGKAFRTK
ENLSHHQRVHSGEKPYTCAECGKSFRWPKGFSIHRRLHLTKRFYECGHCGKGFRHLGFFT
RHQRTHRHGEV
Target Bioclass
Enzyme
Family
Nucleoredoxin family
Subcellular location
Cell projection, cilium, photoreceptor outer segment
Function
Plays an important role in retinal cone photoreceptor survival. In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.
Uniprot ID
Q96CM4
Ensemble ID
ENST00000301944.3
HGNC ID
HGNC:25179

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C148(1.68)  LDD2529  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 NCI-H82 C148(1.68)  LDD2529  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840