Details of the Target

General Information of Target

Target ID LDTP15697
Target Name Primary cilium assembly protein FAM149B1 (FAM149B1)
Gene Name FAM149B1
Gene ID 317662
Synonyms
KIAA0974; Primary cilium assembly protein FAM149B1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTRWSSYLLGWTTFLLYSYESSGGMHEECVFPFTYKGSVYFTCTHIHSLSPWCATRAVYN
GQWKYCQSEDYPRCIFPFIYRGKAYNSCISQGSFLGSLWCSVTSVFDEKQQWKFCETNEY
GGNSLRKPCIFPSIYRNNVVSDCMEDESNKLWCPTTENMDKDGKWSFCADTRISALVPGF
PCHFPFNYKNKNYFNCTNEGSKENLVWCATSYNYDQDHTWVYC
Target Bioclass
Other
Family
FAM149 family
Subcellular location
Cell projection, cilium
Function
Involved in the localization of proteins to the cilium and cilium assembly. Indirectly regulates the signaling functions of the cilium, being required for normal SHH/smoothened signaling and proper development.
Uniprot ID
Q96BN6
Ensemble ID
ENST00000242505.11
HGNC ID
HGNC:29162

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S48G .
HCT15 SNV: p.G78C .
KYSE30 SNV: p.E223G .
RL952 SNV: p.S179Y .
TE4 SNV: p.V506L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		S389(0.00); S393(0.00)  LDD0245  [1]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.