Details of the Target

General Information of Target

Target ID LDTP15690
Target Name Putative monooxygenase p33MONOX (KIAA1191)
Gene Name KIAA1191
Gene ID 57179
Synonyms
P33MONOX; Putative monooxygenase p33MONOX; EC 1.-.-.-; Brain-derived rescue factor p60MONOX; Flavin monooxygenase motif-containing protein of 33 kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQ
YLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVC
SRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPAL
RPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQ
NKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPP
WKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET
Target Bioclass
Enzyme
Family
P33MONOX family
Subcellular location
Cytoplasm
Function Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.
Uniprot ID
Q96A73
Ensemble ID
ENST00000298569.9
HGNC ID
HGNC:29209

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.Y33H .
KYSE180 SNV: p.P47S .
MOLT4 SNV: p.P54H .
NCIH716 SNV: p.P188S .
REH Deletion: p.P57QfsTer2 .
WM2664 Insertion: p.K185Ter; p.G304WfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K156(7.50)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270