Details of the Target

General Information of Target

Target ID LDTP15685
Target Name Copine-4 (CPNE4)
Gene Name CPNE4
Gene ID 131034
Synonyms
Copine-4; Copine IV; Copine-8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALSDVDVKKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKK
EKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSEAKLRLSRIVEDPEVYQGLLDKLV
LQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKHVEVQIDKEAYLAVNAAGG
VEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALFGANTNRKFFI
Target Bioclass
Other
Family
Copine family
Function Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
Uniprot ID
Q96A23
Ensemble ID
ENST00000429747.6
HGNC ID
HGNC:2317

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.D187N .
COLO679 SNV: p.S434L .
G415 SNV: p.G237D .
HEC1 SNV: p.T196I .
JHH7 SNV: p.Y277Ter .
MCC13 SNV: p.D170N .
MDST8 SNV: p.E347K .
MEWO SNV: p.E432K .
NALM6 SNV: p.R454G .
NCIH146 SNV: p.M200L .
NCIH1975 SNV: p.F505L .
NCIH2172 SNV: p.S354N .
PF382 SNV: p.R68H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C88(1.66)  LDD3312  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C88(1.54)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C88(1.55)  LDD2660  [1]
 LDCM0024  KB05 HMCB C88(1.66)  LDD3312  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840