Details of the Target

General Information of Target

Target ID LDTP15673
Target Name Glycine N-acyltransferase-like protein 1 (GLYATL1)
Gene Name GLYATL1
Gene ID 92292
Synonyms
GNAT; Glycine N-acyltransferase-like protein 1; EC 2.3.1.68; Acyl-CoA:glycine N-acyltransferase-like protein 1; Glutamine N-acyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWHLKLCAVLMIFLLLLGQIDGSPIPEVSSAKRRPRRMTPFWRGVSLRPIGASCRDDSEC
ITRLCRKRRCSLSVAQE
Target Bioclass
Enzyme
Family
Glycine N-acyltransferase family
Function Acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor.
Uniprot ID
Q969I3
Ensemble ID
ENST00000300079.9
HGNC ID
HGNC:30519

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.E112Q .
L428 SNV: p.Ter303WextTer14 .
LUDLU1 SNV: p.Y263H .
MEWO SNV: p.P59L .
OVK18 SNV: p.Q83P .
SNU1 SNV: p.T293I .
SW480 SNV: p.P158S .
U2OS SNV: p.R256P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C92(2.31)  LDD3395  [1]
SF
 Probe Info  		N.A.  LDD0028  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C92(2.00)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C92(2.34)  LDD2660  [1]
 LDCM0024  KB05 PC-3 C92(2.31)  LDD3395  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glycine Small molecular drug DB00145

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931