Details of the Target
General Information of Target
| Target ID | LDTP15668 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ribosomal protein uL3-like (RPL3L) | |||||
| Gene Name | RPL3L | |||||
| Gene ID | 6123 | |||||
| Synonyms |
Ribosomal protein uL3-like; 60S ribosomal protein L3-like; Large ribosomal subunit protein uL3-like |
|||||
| 3D Structure | ||||||
| Sequence |
MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAF
LVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRN LTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQ DVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEASYKGHRASKVLFLGNLKKLMST GTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEV SADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRR SESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSELLRPHPLPAERPIFNSMA PASPRLLNQTEKLAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTE NELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNLRMGSEQL |
|||||
| Target Bioclass |
Other
|
|||||
| Family |
Universal ribosomal protein uL3 family
|
|||||
| Function |
Heart- and skeletal muscle-specific component of the ribosome, which regulates muscle function. Component of the large ribosomal subunit in striated muscle cells: replaces the RPL3 paralog in the ribosome in these cells. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Inhibits myotube growth and muscle function.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C253(4.24) | LDD3310 | [1] | |
|
IA-alkyne Probe Info |
 |
C253(0.93); C253(0.82) | LDD2206 | [2] | |
|
IPM Probe Info |
 |
N.A. | LDD2156 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0022 | KB02 | 22RV1 | C253(2.96) | LDD2243 | [1] |
| LDCM0023 | KB03 | 22RV1 | C253(3.09) | LDD2660 | [1] |
| LDCM0024 | KB05 | COLO792 | C253(4.24) | LDD3310 | [1] |
| LDCM0627 | NUDT7-COV-1 | HEK-293T | C253(0.93); C253(0.82) | LDD2206 | [2] |
| LDCM0628 | OTUB2-COV-1 | HEK-293T | C253(0.84); C253(0.74) | LDD2207 | [2] |
References