Details of the Target

General Information of Target

Target ID LDTP15665
Target Name Putative ATP-dependent RNA helicase DDX12 (DDX12P)
Gene Name DDX12P
Synonyms
CHLR2; DDX12; Putative ATP-dependent RNA helicase DDX12; EC 3.6.4.13; CHL1-related protein 2; hCHLR2; DEAD/H box protein 12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW
APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI
SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP
ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS
TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAM
ERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTL
ESSIQGLRIM
Target Bioclass
Enzyme
Family
DEAD box helicase family, DEAH subfamily, DDX11/CHL1 sub-subfamily
Subcellular location
Nucleus
Function DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation.
Uniprot ID
Q92771
HGNC ID
HGNC:2737

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C369(2.12)  LDD3327  [1]
IA-alkyne
 Probe Info  		C369(0.00); C856(0.00); C811(0.00); C75(0.00)  LDD0165  [2]
IPM
 Probe Info  		C655(0.00); C778(0.00); C856(0.00)  LDD2156  [3]
TFBX
 Probe Info  		C369(0.00); C856(0.00)  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C369(1.08)  LDD2171  [5]
 LDCM0022  KB02 ICC10 C369(2.32)  LDD2379  [1]
 LDCM0023  KB03 ICC106 C369(2.60)  LDD2797  [1]
 LDCM0024  KB05 WM115 C369(2.12)  LDD3327  [1]
 LDCM0021  THZ1 HCT 116 C369(1.08)  LDD2173  [5]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.