Details of the Target

General Information of Target

Target ID LDTP15643
Target Name Zinc finger protein 606 (ZNF606)
Gene Name ZNF606
Gene ID 80095
Synonyms
KIAA1852; ZNF328; Zinc finger protein 606; Zinc finger protein 328
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDKSLLLELPILLCCFRALSGSLSMRNDAVNEIVAVKNNFPVIEIVQCRMCHLQFPGEKC
SRGRGICTATTEEACMVGRMFKRDGNPWLTFMGCLKNCADVKGIRWSVYLVNFRCCRSHD
LCNEDL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May act as a transcriptional repressor.
Uniprot ID
Q8WXB4
Ensemble ID
ENST00000341164.9
HGNC ID
HGNC:25879

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K160(5.00)  LDD0277  [1]
DBIA
 Probe Info  		C261(2.33)  LDD3319  [2]
HHS-465
 Probe Info  		K678(0.00); K681(0.00); Y680(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C261(1.16)  LDD2268  [2]
 LDCM0023  KB03 BRX250 C261(2.87)  LDD2686  [2]
 LDCM0024  KB05 MEWO C261(2.33)  LDD3319  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010