Details of the Target

General Information of Target

Target ID LDTP15629
Target Name Zinc finger protein 480 (ZNF480)
Gene Name ZNF480
Gene ID 147657
Synonyms
Zinc finger protein 480
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSQDIFDAIVMADERFHGEGYREGYEEGSSLGVMEGRQHGTLHGAKIGSEIGCYQGFA
FAWKCLLHSCTTEKDSRKMKVLESLIGMIQKFPYDDPTYDKLHEDLDKIRGKFKQFCSLL
NVQPDFKISAEGSGLSF
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Involved in transcriptional regulation as an activator.
Uniprot ID
Q8WV37
Ensemble ID
ENST00000335090.6
HGNC ID
HGNC:23305

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.E311Ter .
HEC1 SNV: p.L63P .
MCC13 SNV: p.N182K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C81(1.19)  LDD3310  [1]
HHS-465
 Probe Info  		K257(0.00); K260(0.00); Y259(0.00)  LDD2240  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 COLO792 C81(1.11)  LDD2476  [1]
 LDCM0023  KB03 G361 C81(1.01)  LDD2894  [1]
 LDCM0024  KB05 COLO792 C81(1.19)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010