Details of the Target

General Information of Target

Target ID LDTP15598
Target Name Large ribosomal subunit protein uL30m (MRPL30)
Gene Name MRPL30
Gene ID 51263
Synonyms
MRPL28; RPML28; Large ribosomal subunit protein uL30m; 39S ribosomal protein L28, mitochondrial; L28mt; MRP-L28; 39S ribosomal protein L30, mitochondrial; L30mt; MRP-L30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMVDPNGNESSATYFILIGLPGLEEAQFWLAFPLCSLYLIAVLGNLTIIYIVRTEHSLHE
PMYIFLCMLSGIDILISTSSMPKMLAIFWFNSTTIQFDACLLQMFAIHSLSGMESTVLLA
MAFDRYVAICHPLRHATVLTLPRVTKIGVAAVVRGAALMAPLPVFIKQLPFCRSNILSHS
YCLHQDVMKLACDDIRVNVVYGLIVIISAIGLDSLLISFSYLLILKTVLGLTREAQAKAF
GTCVSHVCAVFIFYVPFIGLSMVHRFSKRRDSPLPVILANIYLLVPPVLNPIVYGVKTKE
IRQRILRLFHVATHASEP
Target Bioclass
Other
Family
Universal ribosomal protein uL30 family
Subcellular location
Mitochondrion
Uniprot ID
Q8TCC3
Ensemble ID
ENST00000338148.8
HGNC ID
HGNC:14036

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JHH4 SNV: p.D52Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C168(1.24)  LDD3323  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
1d-yne
 Probe Info  		N.A.  LDD0358  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C168(1.04)  LDD2253  [1]
 LDCM0023  KB03 A2058 C168(1.28)  LDD2670  [1]
 LDCM0024  KB05 SKMEL24 C168(1.24)  LDD3323  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264