Details of the Target

General Information of Target

Target ID LDTP15565
Target Name Ras association domain-containing protein 8 (RASSF8)
Gene Name RASSF8
Gene ID 11228
Synonyms
C12orf2; Ras association domain-containing protein 8; Carcinoma-associated protein HOJ-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDSEFLAYVELLDEVEQGSVRAKASSVSLHAERTWMEKMKVEDLNVCEPASPAPEAPAT
SLLNDLKYSPSEEEEVTYTVINQFQQKFGAAILHIKKQNVLSVAAEGANVCRHGKLCWLQ
VATNCRVYLFDIFLLGSRAFHNGLQMILEDKRILKVIHDCRWLSDCLSHQYGILLNNVFD
TQVADVLQFSMETGGYLPNCITTLQESLIKHLQVAPKYLSFLEKRQKLIQENPEVWFIRP
VSPSLLKILALEATYLLPLRLALLDEMMSDLTTLVDGYLNTYREGSADRLGGTEPTCMEL
PEELLQLKDFQKQRREKAAREYRVNAQGLLIRTVLQPKKLVTETAGKEEKVKGFLFGKNF
RIDKAPSFTSQDFHGDVNLLKEESLNKQATNPQHLPPTEEGETSEDSSNKLICTKSKGSE
DQRITQKEHFMTPKHEFQASLSLKEETEQLLMVENKEDLKCTKQAVSMSSFPQETRVSPS
DTFYPIRKTVVSTLPPCPALEKIDSWISPFLNLP
Target Bioclass
Other
Uniprot ID
Q8NHQ8
Ensemble ID
ENST00000282884.13
HGNC ID
HGNC:13232

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.A110SfsTer2 .
NCIH146 SNV: p.T252S .
NCIH446 SNV: p.E223Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C159(2.66)  LDD3410  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]
TFBX
 Probe Info  		C254(0.00); C159(0.00)  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C15(0.93)  LDD1520  [3]
 LDCM0289  AC29 HEK-293T C15(1.02)  LDD1528  [3]
 LDCM0298  AC37 HEK-293T C15(0.88)  LDD1537  [3]
 LDCM0307  AC45 HEK-293T C15(0.90)  LDD1546  [3]
 LDCM0312  AC5 HEK-293T C15(1.10)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C15(0.90)  LDD1555  [3]
 LDCM0325  AC61 HEK-293T C15(1.08)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C15(0.98)  LDD1511  [3]
 LDCM0409  CL21 HEK-293T C15(0.96)  LDD1613  [3]
 LDCM0422  CL33 HEK-293T C15(0.65)  LDD1626  [3]
 LDCM0435  CL45 HEK-293T C15(1.38)  LDD1639  [3]
 LDCM0448  CL57 HEK-293T C15(1.07)  LDD1651  [3]
 LDCM0461  CL69 HEK-293T C15(0.90)  LDD1664  [3]
 LDCM0475  CL81 HEK-293T C15(1.00)  LDD1678  [3]
 LDCM0484  CL9 HEK-293T C15(0.97)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C15(1.00)  LDD1691  [3]
 LDCM0022  KB02 A-375 C159(2.16)  LDD2255  [1]
 LDCM0023  KB03 A-375 C159(2.41)  LDD2672  [1]
 LDCM0024  KB05 RPMI-7951 C159(2.66)  LDD3410  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1) PHOSPHO family Q8TCT1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 2 (ZBTB2) . Q8N680
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Alpha-taxilin (TXLNA) Taxilin family P40222

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402