General Information of Target

Target ID LDTP15528
Target Name Olfactory receptor 4M1 (OR4M1)
Gene Name OR4M1
Gene ID 441670
Synonyms
Olfactory receptor 4M1; Olfactory receptor OR14-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNNSQISTVTQFVLLGFPGPWKIQIIFFSMILLVYIFTLTGNMAIICAVRWDHRLHTPMY
VLLANFSFLEIWYVTCTVPNMLVNFFSKTKTISFSGCFTQFHFFFSLGTTECFFLCVMAY
DRYLAICHPLHYPSIMTGQLCGILVSLCWLIGFLGHSISIFFIFQLPFCGPNIIDHFLCD
VDPLMALSSAPTHIIGHVFHSVSSLFINLTMVYILGSYTLVLRTVLQVPSSAGWQKAIST
CGSHLVVVSLFYGAIMLMYVSPTPGNSVAMHKLITLIYSVVTPVLNPLIYSLRNKDMKYA
LHHVFCGMRIIQRS
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function Olfactory receptor that acts as a receptor of Asprosin hormone, potentially at the surface of hepatocytes and may help to promote hepatocyte glucose release.
Uniprot ID
Q8NGD0
Ensemble ID
ENST00000315957.4
HGNC ID
HGNC:14735

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C47(8.62)  LDD3393  [1]
BTD
 Probe Info 
C47(0.97)  LDD2126  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A204 C47(3.88)  LDD2252  [1]
 LDCM0023  KB03 A204 C47(2.02)  LDD2669  [1]
 LDCM0024  KB05 PaTu 8988t C47(8.62)  LDD3393  [1]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C47(0.97)  LDD2126  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761