Details of the Target

General Information of Target

Target ID LDTP15520
Target Name Probable G-protein coupled receptor 156 (GPR156)
Gene Name GPR156
Gene ID 165829
Synonyms
GABABL; PGR28; Probable G-protein coupled receptor 156; G-protein coupled receptor PGR28; GABAB-related G-protein coupled receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCGRFLRRLLAEESRRSTPVGRLLLPVLLGFRLVLLAASGPGVYGDEQSEFVCHTQQPGC
KAACFDAFHPLSPLRFWVFQVILVAVPSALYMGFTLYHVIWHWELSGKGKEEETLIQGRE
GNTDVPGAGSLRLLWAYVAQLGARLVLEGAALGLQYHLYGFQMPSSFACRREPCLGSITC
NLSRPSEKTIFLKTMFGVSGFCLLFTFLELVLLGLGRWWRTWKHKSSSSKYFLTSESTRR
HKKATDSLPVVETKEQFQEAVPGRSLAQEKQRPVGPRDA
Target Bioclass
GPCR
Family
G-protein coupled receptor 3 family, GABA-B receptor subfamily
Subcellular location
Cell membrane
Function Orphan receptor.
Uniprot ID
Q8NFN8
Ensemble ID
ENST00000461057.1
HGNC ID
HGNC:20844
ChEMBL ID
CHEMBL4523897

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAKI1 SNV: p.F805L .
CAOV3 SNV: p.P728R .
EFO27 SNV: p.Q373K .
HT115 SNV: p.K585N .
IPC298 SNV: p.E533K .
KMRC3 SNV: p.R352K .
LNCaP clone FGC SNV: p.P811T .
LOXIMVI SNV: p.Q550Ter .
MEWO SNV: p.E4K .
OPM2 SNV: p.F70L .
PANC0403 SNV: p.A69P .
SJSA1 Substitution: p.E686_G687delinsDR .
SW1271 SNV: p.V110L .
TYKNU SNV: p.L10F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.