Details of the Target
General Information of Target
| Target ID | LDTP15519 | |||||
|---|---|---|---|---|---|---|
| Target Name | Gap junction gamma-3 protein (GJC3) | |||||
| Gene Name | GJC3 | |||||
| Gene ID | 349149 | |||||
| Synonyms |
GJE1; Gap junction gamma-3 protein; Connexin-30.2; Cx30.2; Connexin-31.3; Cx31.3; Gap junction epsilon-1 protein |
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| 3D Structure | ||||||
| Sequence |
MERGMHLGAAAAGEDDLFLHKSLSASTSKRLEAAFRSTPPGMDLSLAPPPRERPASSSSS
PLGCFEPADPEGAGLLLPPPGGGGGGSAGSGGGGGGGVGVPGLLVGSAGVGGDPSLSSLP AGAALCLKYGESASRGSVAESSGGEQSPDDDSDGRCELVLRAGVADPRASPGAGGGGAKA AEGCSNAHLHGGASVPPGGLGGGGGGGSSSGSSGGGGGSGSGSGGSSSSSSSSSKKSKEQ KALRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQAL EEMRRLVAYLNQGQAISAASLPSSAAAAAAAAALHPALGAYEQAAGYPFSAGLPPAASCP EKCALFNSVSSSLCKQCTEKP |
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| Target Type |
Literature-reported
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| Target Bioclass |
Transporter and channel
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| Family |
Connexin family, Gamma-type subfamily
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| Subcellular location |
Cell membrane
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| Function | One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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N1 Probe Info |
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N.A. | LDD0245 | [1] | |