Details of the Target

General Information of Target

Target ID LDTP15516
Target Name Serine protease 33 (PRSS33)
Gene Name PRSS33
Gene ID 260429
Synonyms
Serine protease 33; EC 3.4.21.-; Serine protease EOS
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE
GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW
LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE
AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR
IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF
ILSRYLPRPADSV
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function Serine protease that has amidolytic activity, cleaving its substrates before Arg residues.
Uniprot ID
Q8NF86
Ensemble ID
ENST00000293851.9
HGNC ID
HGNC:30405

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C28(2.98)  LDD3378  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 8305C C28(2.61)  LDD2248  [1]
 LDCM0023  KB03 8305C C28(2.98)  LDD2665  [1]
 LDCM0024  KB05 OS-RC-2 C28(2.98)  LDD3378  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840