Details of the Target

General Information of Target

Target ID LDTP15511
Target Name Armadillo repeat-containing protein 2 (ARMC2)
Gene Name ARMC2
Gene ID 84071
Synonyms
Armadillo repeat-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDCCMLPYYTAQSSPAMGMFNTSMGKLQRQLYKGEYTIFRYAPMFESDFIQISKRGEVI
DVHNRARMVTMGIVRTSPCLTLPDVMLLARPAAVCDNARCGPATQKRESPPAEILELTRL
LPLMFVKITIHNSVKKQLHLKLATGRSFYLQLCPPSDASEDLFVHWENLVYILRPPVEAY
SDTRAILAGNTLDSSVLEEVQRSPVGYAMKFCEEKEQFRISRLHMNAEMFGSTYCDYTIE
I
Target Bioclass
Other
Function Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability.
Uniprot ID
Q8NEN0
Ensemble ID
ENST00000368972.7
HGNC ID
HGNC:23045

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.K11Ter .
JURLMK1 SNV: p.H836N .
LS180 SNV: p.A612T .
NCIH1793 SNV: p.H707N .
ONS76 SNV: p.K750T .
RKO Deletion: p.L815Ter .
SKMEL24 SNV: p.A480T .
SNGM SNV: p.C437Y .
ZR751 SNV: p.C353Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0166  [1]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060