Details of the Target

General Information of Target

Target ID LDTP15504
Target Name Serine/threonine kinase-like domain-containing protein STKLD1 (STKLD1)
Gene Name STKLD1
Gene ID 169436
Synonyms
C9orf96; SGK071; Serine/threonine kinase-like domain-containing protein STKLD1; Serine/threonine kinase-like domain-containing protein 1; Sugen kinase 071
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVHMLVGVLVMVGFTVGKVPVPDIRTCHFCLVEDPSVGCISGSEKCTISSSSLCMVITI
YYDVKVRFIVRGCGQYISYRCQEKRNTYFAEYWYQAQCCQYDYCNSWSSPQLQSSLPEPH
DRPLALPLSDSQIQWFYQALNLSLPLPNFHAGTEPDGLDPMVTLSLNLGLSFAELRRMYL
FLNSSGLLVLPQAGLLTPHPS
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family, STKL subfamily
Uniprot ID
Q8NE28
Ensemble ID
ENST00000371957.4
HGNC ID
HGNC:28669

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.Q359Ter .
HCT116 SNV: p.R191C .
HEC1 SNV: p.L671P .
HEC1B SNV: p.L671P .
HT SNV: p.S471Y .
IPC298 SNV: p.P196L .
JVM3 SNV: p.V30A .
NB1 SNV: p.Q541Ter .
RL952 SNV: p.W341C .
TE10 SNV: p.Q446H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264