Details of the Target

General Information of Target

Target ID LDTP15488
Target Name Zinc finger protein 485 (ZNF485)
Gene Name ZNF485
Gene ID 220992
Synonyms
Zinc finger protein 485
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRS
WVQPPAADMRRLDWSDSLAQLAQARAALCGIPTPSLASGLWRTLQVGWNMQLLPAGLASF
VEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVC
AYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHG
RLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFH
TCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVI
DSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWN
NQRCKTRNRYICQFAQEHISRWGPGS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q8NCK3
Ensemble ID
ENST00000361807.8
HGNC ID
HGNC:23440

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CALU1 SNV: p.Q253R .
EFO21 SNV: p.I202M .
HCT15 SNV: p.L195M .
HT115 SNV: p.A5T .
IGROV1 SNV: p.Q149R .
NCIH1944 SNV: p.G66V .
NCIH661 SNV: p.A362V .
PANC0403 SNV: p.H232Y .
RL952 SNV: p.S339A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-465
 Probe Info  		K408(0.00); K411(0.00); Y410(0.00)  LDD2240  [1]

References

1 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010