Details of the Target

General Information of Target

Target ID LDTP15476
Target Name Tudor domain-containing protein 5 (TDRD5)
Gene Name TDRD5
Gene ID 163589
Synonyms
TUDOR3; Tudor domain-containing protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPQPPPPAQGSPPHRGRGRGRGRGRGRGRGRGRGGAGAPRAPLPCPTCGRLFRFPYYLS
RHRLSHSGLRPHACPLCPKAFRRPAHLSRHLRGHGPQPPLRCAACPRTFPEPAQLRRHLA
QEHAGGEVELAIERVAKETAEPSWGPQDEGSEPPTTAAAGATEEEAVAAWPETWPAGEPS
TLAAPTSAAEPRESESEEAEAGAAELRAELALAAGRQEEKQVLLQADWTLLCLRCREAFA
TKGELKAHPCLRPEGEQEGEGGPPPRPKRHQCSICLKAFARPWSLSRHRLVHSTDRPFVC
PDCGLAFRLASYLRQHRRVHGPLSLLAPLPAAGKKDDKASGARNSAKGPEGGEGAECGGA
SEGGEGQNGGDAAPARPPAGEPRFWCPECGKGFRRRAHLRQHGVTHSGARPFQCVRCQRE
FKRLADLARHAQVHAGGPAPHPCPRCPRRFSRAYSLLRHQRCHRAELERAAALQALQAQA
PTSPPPPPPPLKAEQEEEGLPLPLANIKEEPPSPGTPPQSPPAPPVFLSASCFDSQDHSA
FEMEEEEVDSKAHLRGLGGLAS
Target Bioclass
Other
Family
TDRD5 family
Subcellular location
Cytoplasm
Function
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly.
Uniprot ID
Q8NAT2
Ensemble ID
ENST00000294848.12
HGNC ID
HGNC:20614

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.T266I .
CCK81 SNV: p.T904A .
COLO792 SNV: p.E796A; p.E831K .
DU145 SNV: p.T973I .
HCT15 SNV: p.Q29H .
IGR37 SNV: p.S670N .
IGR39 SNV: p.S670N .
IM95 Insertion: p.L336IfsTer14 .
IPC298 SNV: p.P1003S .
JURKAT SNV: p.K949R .
MELJUSO SNV: p.S967F .
MEWO SNV: p.G808R .
NCIH446 SNV: p.A871T .
OVK18 Deletion: p.K335NfsTer2 .
U118MG SNV: p.S96R .
UACC257 SNV: p.T53I .
WM2664 Insertion: p.T788SfsTer4 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [1]

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853