Details of the Target

General Information of Target

Target ID LDTP15472
Target Name Probable E3 ubiquitin-protein ligase TRIML1 (TRIML1)
Gene Name TRIML1
Gene ID 339976
Synonyms
RNF209; Probable E3 ubiquitin-protein ligase TRIML1; EC 2.3.2.27; RING finger protein 209; RING-type E3 ubiquitin transferase TRIML1; Tripartite motif family-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKMHFCIPVSQQRSDALGGRYVLYSVHLDGFLFCRVRYSQLHGWNEQLRRVFGNCLPPFP
PKYYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFLKLAQLNTFDIATKKAYLD
IFLPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLA
DFELPYVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIEKGWAKPT
QAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTCDYPESGSGAVLSVGNNEISCC
ITLPDSQTQDIVFQMSRVKCWQVTFLGTLLDTDGPQRTLNQNLELRFQYSEDSCWQWFVI
YTKQAFLLSSCLKKMISEKMVKLAAENTEMQIEVPEQSKSKKYHIQQSQQKDYSSFLSRK
SKIKIAKDDCVFGNIKEEDL
Target Bioclass
Enzyme
Function Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.
Uniprot ID
Q8N9V2
Ensemble ID
ENST00000332517.4
HGNC ID
HGNC:26698

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C405(0.96)  LDD2171  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C405(0.96)  LDD2171  [1]
 LDCM0021  THZ1 HCT 116 C405(0.96)  LDD2173  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.