Details of the Target

General Information of Target

Target ID LDTP15469
Target Name Exonuclease mut-7 homolog (EXD3)
Gene Name EXD3
Gene ID 54932
Synonyms
Exonuclease mut-7 homolog; EC 3.1.-.-; Exonuclease 3'-5' domain-containing protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT
VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL
LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ
ELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQ
IVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDV
ARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTAL
QGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEF
MTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLLNR
A
Target Bioclass
Enzyme
Family
Mut-7 family
Function Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs.
Uniprot ID
Q8N9H8
Ensemble ID
ENST00000340951.9
HGNC ID
HGNC:26023

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 SNV: p.Q728H .
HCT15 SNV: p.L26M .
JVM3 SNV: p.D21E .
NCIH1993 Deletion: p.L140WfsTer23 .
OPM2 SNV: p.G294W .
REH SNV: p.A320T; p.A768V .
RL952 SNV: p.Q295Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C476(1.55)  LDD2268  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C476(1.55)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C476(6.07)  LDD2685  [1]
 LDCM0024  KB05 BRX211 C476(2.64)  LDD3102  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840