Details of the Target

General Information of Target

Target ID LDTP15393
Target Name T-cell activation Rho GTPase-activating protein (TAGAP)
Gene Name TAGAP
Gene ID 117289
Synonyms
TAGAP1; T-cell activation Rho GTPase-activating protein; T-cell activation GTPase-activating protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSAPASGSVRARYLVYFQYVGTDFNGVAAVRGTQRAVGVQNYLEEAAERLNSVEPVRFT
ISSRTDAGVHALSNAAHLDVQRRSGRPPFPPEVLAEALNTHLRHPAIRVLRAFRVPSDFH
ARHAATSRTYLYRLATGCHRRDELPVFERNLCWTLPADCLDMVAMQEAAQHLLGTHDFSA
FQSAGSPVPSPVRTLRRVSVSPGQASPLVTPEESRKLRFWNLEFESQSFLYRQVRRMTAV
LVAVGLGALAPAQVKTILESQDPLGKHQTRVAPAHGLFLKSVLYGNLGAASCTLQGPQFG
SHG
Target Bioclass
Other
Function May function as a GTPase-activating protein and may play important roles during T-cell activation.
Uniprot ID
Q8N103
Ensemble ID
ENST00000326965.7
HGNC ID
HGNC:15669

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.A599T .
HCT15 SNV: p.S326G .
HT115 SNV: p.F484V; p.R711Ter .
IM95 SNV: p.R453W .
Ishikawa (Heraklio) 02 ER SNV: p.N523Y .
LS180 Deletion: p.V151CfsTer44 .
MCC13 SNV: p.E546K .
MEWO SNV: p.D579N .
OVK18 SNV: p.R711Ter .
RL SNV: p.F158C .
RL952 SNV: p.R544Ter .
TOV21G SNV: p.L21V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C713(5.41)  LDD1707  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell C713(5.41)  LDD1707  [1]
 LDCM0024  KB05 T cell C713(20.00)  LDD1709  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.