Details of the Target

General Information of Target

Target ID	LDTP15349
Target Name	F-box only protein 16 (FBXO16)
Gene Name	FBXO16
Gene ID	157574
Synonyms	FBX16; F-box only protein 16
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSRFPAVAGRAPRRQEEGERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRK KIIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRKVAAISVAQRVAE EMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTL TTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREK FCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVD YDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYV VDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPD HVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVT RLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRH RELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKL KQQSDFPKETFEGPKHEVLRRCLCAGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHE QETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDAR RRWTNKENVKQLKDGISKDVLKKMQRRNDDKSISDARARFLERKQQRTQDHSDTRKETG
Target Bioclass	Other
Function	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Uniprot ID	Q8IX29
Ensemble ID	ENST00000380254.7
HGNC ID	HGNC:13618

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
CAL27	SNV: p.H164Y	.
IGR1	SNV: p.K268T	.
KYM1	Insertion: p.L109PfsTer16	.
LS180	SNV: p.S280A	.
MCC13	SNV: p.S197L	.
NCIH1155	SNV: p.A179V	.
OCUM1	SNV: p.A40V	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
W1 Probe Info			Y156(0.00); H155(0.00)	LDD0236	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Tripartite motif-containing protein 54 (TRIM54)				.	Q9BYV2

Other

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Mortality factor 4-like protein 2 (MORF4L2)	.	Q15014
NTF2-related export protein 1 (NXT1)	.	Q9UKK6
Rhombotin-1 (LMO1)	.	P25800

References

1	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.