Details of the Target

General Information of Target

Target ID LDTP15327
Target Name Testis development-related protein (TDRP)
Gene Name TDRP
Gene ID 157695
Synonyms
C8orf42; Testis development-related protein; Protein INM01
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQSCEEEKEPEPQKNIQETKQVDDEDAELIFVGVEHVNEDAELIFVGVTSNSKPVVSNI
LNRVTPGSWSRRKKYDHLRKDTARKLQPKSHETVTSEAVTVLPASQLESRSTDSPIIIEP
LSKPDYRNSSPQVVPNNSSELPSPLITFTDSLHHPVSTALSVGGINESPRVSKQLSTFEV
NSINPKRAKLRDGIIEGNSSASFPSDTFHTMNTQQSTPSNNVHTSLSHVQNGAPFPAAFP
KDNIHFKPINTNLDRANELAKTDILSLTSQNKTFDPKKENPIVLLSDFYYGQHKGEGQPE
QKTHTTFKCLSCVKVLKNVKFMNHVKHHLEFEKQRNDSWENHTTCQHCHRQFPTPFQLQC
HIENVHTAQEPSTVCKICELSFETDQVLLQHMKDHHKPGEMPYVCQVCHYRSSVFADVET
HFRTCHENTKNLLCPFCLKIFKTATPYMCHYRGHWGKSAHQCSKCRLQFLTFKEKMEHKT
QCHQMFKKPKQLEGLPPETKVTIQVSLEPLQPGSVDVASITVSTSDSEPSLPRSKSKISK
KSH
Target Bioclass
Other
Family
TDRP family
Subcellular location
Nucleus
Function Contributes to normal sperm motility, but not essential for male fertility.
Uniprot ID
Q86YL5
Ensemble ID
ENST00000324079.11
HGNC ID
HGNC:26951

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GB1 SNV: p.G39E .
HCT116 SNV: p.E183D .
HCT15 SNV: p.L114I .
HT115 SNV: p.R170Q .
HUCCT1 SNV: p.G108D .
SUPT1 SNV: p.A33T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.05  LDD0402  [1]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.