Details of the Target

General Information of Target

Target ID LDTP15321
Target Name Insulin-like growth factor-binding protein 3 receptor (TMEM219)
Gene Name TMEM219
Gene ID 124446
Synonyms
Insulin-like growth factor-binding protein 3 receptor; IGFBP-3R; Transmembrane protein 219
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLRDLVLRRGCCWSSLLLHCALHPLWGFVQVTHGEPQKSCSKVTDSCRHVCQCRPPPPL
PPPPPPPPPPRLLSAPAPNSTSCPTEESWWSGLVIIIAVCCASLVFLTVLVIICYKAIKR
KPLRKDENGTSVAEYPMSASQSNKGVDVNNAVV
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cell membrane
Function Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.
TTD ID
T02328
Uniprot ID
Q86XT9
DrugMap ID
TTY078U
Ensemble ID
ENST00000279396.11
HGNC ID
HGNC:25201

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2224  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C70(20.00)  LDD2227  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-13 receptor subunit alpha-2 (IL13RA2) Type I cytokine receptor family Q14627
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Insulin-like growth factor-binding protein 3 (IGFBP3) . P17936

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019