Details of the Target

General Information of Target

Target ID LDTP15314
Target Name Sorting nexin-32 (SNX32)
Gene Name SNX32
Gene ID 254122
Synonyms
SNX6B; Sorting nexin-32; Sorting nexin-6B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDSTSSLHGSSLHRPSTEQTRTDFSWDGINLSMEDTTSILPKLKRNSNAYGIGALAKSSF
SGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKTPAVQPQHSHESVRRDTDAYSDLSDGE
KEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLGCNYSDNYQELMDSQDALAQ
APMDGWPHSYVSQGMYCLGSSDAWEASDQSLIASPATGSYLGPAFDDSQPSLHEMGPSQP
ASGYSALEPPPLLGGDTDWAPGVGAVDLARGPAEEEKRPLAPEEEEDAGCRDLESLSPRE
DPEMSTALSRKVSDVTSSGVQSFDEEEGEANN
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Function May be involved in several stages of intracellular trafficking.
Uniprot ID
Q86XE0
Ensemble ID
ENST00000308342.7
HGNC ID
HGNC:26423

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.Y163N; p.C344S .
KYSE30 SNV: p.M197R .
MDAMB453 SNV: p.S364F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C49(1.13)  LDD2397  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 IGR-39 C49(1.13)  LDD2397  [1]
 LDCM0023  KB03 CHL1 C49(2.72)  LDD2877  [1]
 LDCM0024  KB05 CHL1 C49(2.42)  LDD3294  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840