Details of the Target

General Information of Target

Target ID LDTP15280
Target Name Sarcalumenin (SRL)
Gene Name SRL
Gene ID 6345
Synonyms
Sarcalumenin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSIALKQVFNKDKTFRPKRKFEPGTQRFELHKRAQASLNSGVDLKAAVQLPSGEDQNDWV
AVHVVDFFNRINLIYGTICEFCTERTCPVMSGGPKYEYRWQDDLKYKKPTALPAPQYMNL
LMDWIEVQINNEEIFPTCVGVPFPKNFLQICKKILCRLFRVFVHVYIHHFDRVIVMGAEA
HVNTCYKHFYYFVTEMNLIDRKELEPLKEMTSRMCH
Target Bioclass
Enzyme
Family
TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
Subcellular location
Sarcoplasmic reticulum lumen
Uniprot ID
Q86TD4
Ensemble ID
ENST00000399609.7
HGNC ID
HGNC:11295

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C670(0.73)  LDD3351  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 NCI-H196 C670(1.46)  LDD2517  [1]
 LDCM0023  KB03 NCI-H146 C670(0.52)  LDD2927  [1]
 LDCM0024  KB05 NCI-H196 C670(0.73)  LDD3351  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840