Details of the Target

General Information of Target

Target ID LDTP15272
Target Name Protein zer-1 homolog (ZER1)
Gene Name ZER1
Gene ID 10444
Synonyms
C9orf60; ZYG; ZYG11BL; Protein zer-1 homolog; Hzyg; Zyg-11 homolog B-like protein; Zyg11b-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFG
LFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFFFCN
TATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILA
IIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVLPCP
VAHSQGP
Target Bioclass
Other
Family
Zyg-11 family
Function
Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition elements. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N-myristoylation.
Uniprot ID
Q7Z7L7
Ensemble ID
ENST00000291900.7
HGNC ID
HGNC:30960

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C577(3.45)  LDD3345  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
Acrolein
 Probe Info  		N.A.  LDD0217  [3]
NAIA_5
 Probe Info  		C754(0.00); C718(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C337(1.22)  LDD1093  [5]
 LDCM0279  AC2 PaTu 8988t C337(1.03)  LDD1158  [5]
 LDCM0290  AC3 PaTu 8988t C337(1.15)  LDD1169  [5]
 LDCM0301  AC4 PaTu 8988t C337(0.88)  LDD1180  [5]
 LDCM0312  AC5 PaTu 8988t C337(1.04)  LDD1191  [5]
 LDCM0332  AC68 PaTu 8988t C337(1.38)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C337(1.39)  LDD1212  [5]
 LDCM0335  AC70 PaTu 8988t C337(1.30)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C337(1.20)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C337(1.48)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C337(1.45)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C337(0.99)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C337(1.65)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C337(1.52)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C337(1.12)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C337(1.01)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C337(1.61)  LDD1223  [5]
 LDCM0346  AC80 PaTu 8988t C337(1.15)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C337(1.11)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C337(1.46)  LDD1227  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0369  CL100 PaTu 8988t C337(0.88)  LDD1248  [5]
 LDCM0403  CL16 PaTu 8988t C337(1.11)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C337(0.73)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C337(0.97)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C337(1.30)  LDD1285  [5]
 LDCM0408  CL20 PaTu 8988t C337(0.70)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C337(0.79)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C337(0.91)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C337(0.94)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C337(0.92)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C337(1.18)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C337(0.75)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C337(0.92)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C337(0.66)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C337(0.72)  LDD1296  [5]
 LDCM0419  CL30 PaTu 8988t C337(1.39)  LDD1298  [5]
 LDCM0469  CL76 PaTu 8988t C337(0.96)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C337(1.10)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C337(1.15)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C337(1.11)  LDD1351  [5]
 LDCM0474  CL80 PaTu 8988t C337(1.16)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C337(1.14)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C337(1.00)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C337(1.25)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C337(0.76)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C337(1.09)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C337(1.28)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C337(1.11)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C337(1.32)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C337(1.11)  LDD1362  [5]
 LDCM0485  CL90 PaTu 8988t C337(1.24)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C337(0.94)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C337(0.73)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C337(0.86)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C337(1.04)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C337(1.02)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C337(0.56)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C337(0.89)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C337(0.80)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C337(0.87)  LDD1373  [5]
 LDCM0022  KB02 Calu-1 C577(2.12)  LDD2292  [1]
 LDCM0023  KB03 Calu-1 C577(5.02)  LDD2709  [1]
 LDCM0024  KB05 NCI-H1650 C577(3.45)  LDD3345  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.