Details of the Target

General Information of Target

Target ID LDTP15260
Target Name Probable G-protein coupled receptor 142 (GPR142)
Gene Name GPR142
Gene ID 350383
Synonyms
PGR2; Probable G-protein coupled receptor 142; G-protein coupled receptor PGR2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAQDCQAAASPEPPGPPARSCVAAWWDMVDRNLRYFPHSCSMLGRKIAALYDSFTSKSL
KEHVFLPLIDMLIYFNFFKAPFLVDLKKPELKIPHTVNFYLRVEPGVMLGIWHTVPSCRG
EDAKGKDCCWYEAALRDGNPIIVYLHGSAEHRAASHRLKLVKVLSDGGFHVLSVDYRGFG
DSTGKPTEEGLTTDAICVYEWTKARSGITPVCLWGHSLGTGVATNAAKVLEEKGCPVDAI
VLEAPFTNMWVASINYPLLKIYRNIPGFLRTLMDALRKDKIIFPNDENVKFLSSPLLILH
GEDDRTVPLEYGKKLYEIARNAYRNKERVKMVIFPPGFQHNLLCKSPTLLITVRDFLSKQ
WS
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function Orphan receptor.
Uniprot ID
Q7Z601
Ensemble ID
ENST00000335666.4
HGNC ID
HGNC:20088
ChEMBL ID
CHEMBL2069161

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C84(3.38)  LDD3377  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 8305C C84(5.21)  LDD2248  [1]
 LDCM0023  KB03 8305C C84(2.06)  LDD2665  [1]
 LDCM0024  KB05 OPM-2 C84(3.38)  LDD3377  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840