Details of the Target

General Information of Target

Target ID LDTP15241
Target Name D-glutamate cyclase, mitochondrial (DGLUCY)
Gene Name DGLUCY
Gene ID 80017
Synonyms
C14orf159; D-glutamate cyclase, mitochondrial; EC 4.2.1.48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGRHQNRSFPLPGVQSSGQVHAFGNCSDSDILEEDAEVYELRSRGKEKVRRSTSRDRLD
DIIVLTKDIQEGDTLNAIALQYCCTVADIKRVNNLISDQDFFALRSIKIPVKKFSSLTET
LCPPKGRQTSRHSSVQYSSEQQEILPANDSLAYSDSAGSFLKEVDRDIEQIVKCTDNKRE
NLNEVVSALTAQQMRFEPDNKNTQRKDPYYGADWGIGWWTAVVIMLIVGIITPVFYLLYY
EILAKVDVSHHSTVDSSHLHSKITPPSQQREMENGIVPTKGIHFSQQDDHKLYSQDSQSP
AAQQET
Target Bioclass
Enzyme
Family
D-glutamate cyclase family
Subcellular location
Mitochondrion matrix
Function D-glutamate cyclase that converts D-glutamate to 5-oxo-D-proline.
Uniprot ID
Q7Z3D6
Ensemble ID
ENST00000256324.15
HGNC ID
HGNC:20498

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C270(2.81)  LDD3311  [3]
IA-alkyne
 Probe Info  		C265(6.21)  LDD1706  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0022  KB02 HEK-293T C265(0.98)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C265(1.05)  LDD1497  [5]
 LDCM0024  KB05 G361 C270(2.81)  LDD3311  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) MsrB Met sulfoxide reductase family Q9Y3D2
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402