Details of the Target

General Information of Target

Target ID	LDTP15178
Target Name	Kinesin-like protein KIF6 (KIF6)
Gene Name	KIF6
Gene ID	221458
Synonyms	C6orf102; Kinesin-like protein KIF6
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGLSDELVLVDVDEGKLKG ETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKKGETRLDLVQRNVSIFKLM IPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIGSGCNLDSARFRYFIGQRLGI HSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDIGTDKDPEQWENVHKKVISSGYE MVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTLSKGLYGINEDIFLSVPCILGENGI TDLIKVKLTLEEEACLQKSAETLWEIQKELKL
Target Bioclass	Enzyme
Family	TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Subcellular location	Cytoplasm, cytoskeleton
Uniprot ID	Q6ZMV9
Ensemble ID	ENST00000229913.9
HGNC ID	HGNC:21202
ChEMBL ID	CHEMBL3308907

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
A3KAW	SNV: p.R42C	.
CAL27	SNV: p.D116N	.
DU145	SNV: p.P159L	.
HEC1	SNV: p.T228I	.
HEC1B	SNV: p.T228I	.
Ishikawa (Heraklio) 02 ER	SNV: p.T379I	.
KMCH1	SNV: p.A416S	.
KPL1	Deletion: p.R600del	.
MCF7	Deletion: p.R600del	.
MFE319	SNV: p.T400A	.
MOLT4	SNV: p.R383M	.
NCIH23	SNV: p.Q616Ter	.
NCIH446	SNV: p.V360M; p.G730C	.
NUGC3	SNV: p.K234Q	.
ONS76	SNV: p.M522I	.
OVK18	SNV: p.N597S	.
RPMI8226	SNV: p.G261V	.
SKMEL3	SNV: p.L156F	.
SNGM	SNV: p.F74S	.
SUIT2	SNV: p.G737D	.
WM1552C	SNV: p.V283D	.
WM2664	Insertion: p.I575HfsTer3	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
Crotonaldehyde Probe Info			N.A.	LDD0219	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Amyloid protein-binding protein 2 (APPBP2)				.	Q92624

References

1	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.