Details of the Target

General Information of Target

Target ID LDTP15173
Target Name Repetin (RPTN)
Gene Name RPTN
Gene ID 126638
Synonyms
Repetin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMRTCVLLSAVLWCLTGVQCPRFTLFNKKGFIYGKTGQPDKIYVELHQNSPVLICMDFKL
SKKEIVDPTYLWIGPNEKTLTGNNRINITETGQLMVKDFLEPLSGLYTCTLSYKTVKAET
QEEKTVKKRYDFMVFAYREPDYSYQMAVRFTTRSCIGRYNDVFFRVLKKILDSLISDLSC
HVIEPSYKCHSVEIPEHGLIHELFIAFQVNPFAPGWKGACNGSVDCEDTTNHNILQARDR
IEDFFRSQAYIFYHNFNKTLPAMHFVDHSLQVVRLDSCRPGFGKNERLHSNCASCCVVCS
PATFSPDVNVTCQTCVSVLTYGAKSCPQTSNKNQQYED
Target Bioclass
Other
Family
S100-fused protein family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.
Uniprot ID
Q6XPR3
Ensemble ID
ENST00000316073.3
HGNC ID
HGNC:26809

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C352(1.54)  LDD3373  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC20 C111(1.80); C283(1.34); C673(1.85)  LDD2387  [1]
 LDCM0023  KB03 ICC20 C283(1.34); C673(2.29)  LDD2804  [1]
 LDCM0024  KB05 OCUG-1 C352(1.54)  LDD3373  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840