Details of the Target

General Information of Target

Target ID	LDTP15150
Target Name	Insulin growth factor-like family member 2 (IGFL2)
Gene Name	IGFL2
Gene ID	147920
Synonyms	Insulin growth factor-like family member 2
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MKPVWVATLLWMLLLVPRLGAARKGSPEEASFYYGTFPLGFSWGVGSSAYQTEGAWDQDG KGPSIWDVFTHSGKGKVLGNETADVACDGYYKVQEDIILLRELHVNHYRFSLSWPRLLPT GIRAEQVNKKGIEFYSDLIDALLSSNITPIVTLHHWDLPQLLQVKYGGWQNVSMANYFRD YANLCFEAFGDRVKHWITFSDPRAMAEKGYETGHHAPGLKLRGTGLYKAAHHIIKAHAKA WHSYNTTWRSKQQGLVGISLNCDWGEPVDISNPKDLEAAERYLQFCLGWFANPIYAGDYP QVMKDYIGRKSAEQGLEMSRLPVFSLQEKSYIKGTSDFLGLGHFTTRYITERNYPSRQGP SYQNDRDLIELVDPNWPDLGSKWLYSVPWGFRRLLNFAQTQYGDPPIYVMENGASQKFHC TQLCDEWRIQYLKGYINEMLKAIKDGANIKGYTSWSLLDKFEWEKGYSDRYGFYYVEFND RNKPRYPKASVQYYKKIIIANGFPNPREVESWYLKALETCSINNQMLAAEPLLSHMQMVT EIVVPTVCSLCVLITAVLLMLLLRRQS
Target Bioclass	Other
Family	IGFL family
Subcellular location	Secreted
Function	Potential ligand of the IGFLR1 cell membrane receptor.
Uniprot ID	Q6UWQ7
Ensemble ID	ENST00000377693.5
HGNC ID	HGNC:32929

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
42MGBA	SNV: p.C51Y			.
SNU1	Deletion: p.C70AfsTer23			.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
Acrolein Probe Info			N.A.	LDD0232	[1]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0109	NEM	HeLa	N.A.	LDD0232	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Pituitary homeobox 1 (PITX1)				Paired homeobox family	P78337
T-cell leukemia homeobox protein 3 (TLX3)				.	O43711

References

1	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.