Details of the Target

General Information of Target

Target ID LDTP15146
Target Name Transmembrane and coiled-coil domain-containing protein 3 (TMCO3)
Gene Name TMCO3
Gene ID 55002
Synonyms
C13orf11; Transmembrane and coiled-coil domain-containing protein 3; Putative LAG1-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLTPEPPSGRVEGPPAWEAAPWPSLPCGPCIPIMLVLATLAALFILTTAVLAERLFRRA
LRPDPSHRAPTLVWRPGGELWIEPMGTARERSEDWYGSAVPLLTDRAPEPPTQVGTLEAR
ATAPPAPSAPNSAPSNLGPQTVLEVPARSTFWGPQPWEGRPPATGLVSWAEPEQRPEASV
QFGSPQARRQRPGSPDPEWGLQPRVTLEQISAFWKREGRTSVGF
Target Bioclass
Transporter and channel
Family
Monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
Subcellular location
Membrane
Function Probable Na(+)/H(+) antiporter.
Uniprot ID
Q6UWJ1
Ensemble ID
ENST00000375391.5
HGNC ID
HGNC:20329

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.L472FfsTer6 .
A549 SNV: p.M179I .
CCK81 SNV: p.G537C .
CMK Deletion: p.L584CfsTer5 .
HCT15 SNV: p.S46I .
HEC1 SNV: p.V93M .
HEC1B SNV: p.V93M .
HT115 SNV: p.F333S .
IGR1 SNV: p.V416L .
NCIH2291 Deletion: p.E195GfsTer4 .
RH30 Deletion: p.R604del .
SW1116 SNV: p.S134T .
TOV21G SNV: p.L510S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C667(1.82)  LDD2337  [1]
TFBX
 Probe Info  		N.A.  LDD0027  [2]
Acrolein
 Probe Info  		H269(0.00); H25(0.00)  LDD0217  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HCC1187 C667(1.82)  LDD2337  [1]
 LDCM0023  KB03 HCC1187 C667(8.26)  LDD2754  [1]
 LDCM0024  KB05 HCC1187 C667(5.35)  LDD3171  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.