Details of the Target

General Information of Target

Target ID LDTP15137
Target Name SCAN domain-containing protein 3 (SCAND3)
Gene Name SCAND3
Gene ID 114821
Synonyms
Buster4; KIAA1925; ZBED9; ZNF305P2; ZNF452; SCAN domain-containing protein 3; Transposon-derived Buster4 transposase-like protein; Zinc finger BED domain-containing protein 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFI
VLPLAKTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNI
TEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHS
VCWNSNGSLLATTCKDKTLRIIDPRKGQVVAEQARPHEGARPLRAVFTADGKLLSTGFSR
MSERQLALWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEP
PFVHYLNTFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERKCEPIIMTVPRKSDLFQD
DLYPDTPGPEPALEADEWLSGQDAEPVLISLRDGYVPPKHRELRVTKRNILDVRPPSGPR
RSQSASDAPLSQQHTLETLLEEIKALRERVQAQEQRITALENMLCELVDGTD
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q6R2W3
Ensemble ID
ENST00000452236.3
HGNC ID
HGNC:13851

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C59(1.74)  LDD0078  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C59(1.04)  LDD1520  [3]
 LDCM0289  AC29 HEK-293T C59(1.08)  LDD1528  [3]
 LDCM0298  AC37 HEK-293T C59(1.11)  LDD1537  [3]
 LDCM0307  AC45 HEK-293T C59(1.08)  LDD1546  [3]
 LDCM0312  AC5 HEK-293T C59(1.01)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C59(1.09)  LDD1555  [3]
 LDCM0325  AC61 HEK-293T C59(1.07)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C59(1.14)  LDD1511  [3]
 LDCM0020  ARS-1620 HCC44 C59(1.74)  LDD0078  [1]
 LDCM0409  CL21 HEK-293T C59(1.08)  LDD1613  [3]
 LDCM0422  CL33 HEK-293T C59(1.08)  LDD1626  [3]
 LDCM0435  CL45 HEK-293T C59(1.10)  LDD1639  [3]
 LDCM0448  CL57 HEK-293T C59(1.21)  LDD1651  [3]
 LDCM0461  CL69 HEK-293T C59(1.10)  LDD1664  [3]
 LDCM0475  CL81 HEK-293T C59(1.03)  LDD1678  [3]
 LDCM0484  CL9 HEK-293T C59(1.03)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C59(1.11)  LDD1691  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402