Details of the Target

General Information of Target

Target ID LDTP15126
Target Name Zinc finger protein 613 (ZNF613)
Gene Name ZNF613
Gene ID 79898
Synonyms
Zinc finger protein 613
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWMFLRDLLSGVNKYSTGTGWIWLAVVFVFRLLVYMVAAEHVWKDEQKEFECNSRQPGC
KNVCFDDFFPISQVRLWALQLIMVSTPSLLVVLHVAYHEGREKRHRKKLYVSPGTMDGGL
WYAYLISLIVKTGFEIGFLVLFYKLYDGFSVPYLIKCDLKPCPNTVDCFISKPTEKTIFI
LFLVITSCLCIVLNFIELSFLVLKCFIKCCLQKYLKKPQVLSV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q6PF04
Ensemble ID
ENST00000293471.11
HGNC ID
HGNC:25827

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCLP1 Substitution: p.E617Ter .
IM95 SNV: p.C346Y .
KMCH1 SNV: p.K81R; p.T227N .
KMRC20 SNV: p.L331V .
KMS11 SNV: p.E170Ter .
LNCaP clone FGC SNV: p.Q102Ter .
NCIH358 SNV: p.A581G .
P31FUJ SNV: p.G48E .
SKMEL28 SNV: p.G317E .
SW403 SNV: p.V15L .
TCCSUP SNV: p.R613T .
YSCCC SNV: p.D516H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C442(1.43)  LDD3383  [1]
N1
 Probe Info  		H194(0.00); R196(0.00)  LDD0245  [2]
1d-yne
 Probe Info  		N.A.  LDD0356  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C442(2.44)  LDD2250  [1]
 LDCM0023  KB03 A2780 C442(1.69)  LDD2671  [1]
 LDCM0024  KB05 OVCAR-5 C442(1.43)  LDD3383  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 5-7 (KRTAP5-7) KRTAP type 5 family Q6L8G8
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Four and a half LIM domains protein 5 (FHL5) . Q5TD97

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.