General Information of Target

Target ID LDTP15121
Target Name GTPase IMAP family member 6 (GIMAP6)
Gene Name GIMAP6
Gene ID 474344
Synonyms
IAN2; IAN6; GTPase IMAP family member 6; Immunity-associated nucleotide 2 protein; IAN-2; hIAN2; Immunity-associated nucleotide 6 protein; IAN-6; hIAN6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAPRAALVFALVIALVPVGRGNYEELENSGDTTVESERPNKVTIPSTFAAVTIKETLNA
NINSTNFAPDENQLEFILMVLIPLILLVLLLLSVVFLATYYKRKRTKQEPSSQGSQSALQ
TYELGSENVKVPIFEEDTPSVMEIEMEELDKWMNSMNRNADFECLPTLKEEKESNHNPSD
SES
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
Subcellular location
Cytoplasm, cytosol
Uniprot ID
Q6P9H5
Ensemble ID
ENST00000328902.9
HGNC ID
HGNC:21918

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.E12K .
COLO792 SNV: p.E278K .
DU145 SNV: p.L215R .
DU4475 SNV: p.T158I .
IPC298 SNV: p.P22S .
MCC26 Substitution: p.R39K .
MOLT4 SNV: p.I116T .
SKMEL24 SNV: p.G57E .
WM793 SNV: p.E281K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C197(11.77)  LDD0209  [1]
4-Iodoacetamidophenylacetylene
 Probe Info 
N.A.  LDD0038  [2]
IA-alkyne
 Probe Info 
C113(0.00); C197(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info 
N.A.  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Jurkat C197(1.95)  LDD2409  [3]
 LDCM0023  KB03 Jurkat C197(11.77)  LDD0209  [1]
 LDCM0024  KB05 PF-382 C197(2.73)  LDD3397  [3]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840